New antihypertensive agents. III. Synthesis and antihypertensive activity of some arylalkyl piperidines carrying a heterocycle at the 4-position.
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چکیده
منابع مشابه
Synthesis and antihypertensive activity of some new quinazoline derivatives.
A series of substituted 2-piperidino-4-amino-6,7-dimethoxyquinazolines was synthesized and screened as potential antihypertensive agents. The hypotensive effect of all the new compounds was studied after intravenous administrations in urethane-anesthetized normotensive rats. The furoylpiperazine moiety in the prazosin molecule could be replaced by a more stable substituted piperidine group with...
متن کاملSynthesis and Antihypertensive Activity of Some Novel Pyridazinones
Four pyridazinones (2-5) were synthesized by the reaction of 3-benzoylpropionic acid with the corresponding hydrazines. These pyridazinones were further derivatized with appropriate aromatic aldehydes in the presence of piperidine to obtain the desired compounds (6-13). The chemical structures of the synthesized pyridazinones were elucidated on the basis of their spectral analysis (IR, 1H-NMR, ...
متن کاملSynthesis and Antihypertensive Activity of Some Novel Pyridazinones
Four pyridazinones (2-5) were synthesized by the reaction of 3-benzoylpropionic acid with the corresponding hydrazines. These pyridazinones were further derivatized with appropriate aromatic aldehydes in the presence of piperidine to obtain the desired compounds (6-13). The chemical structures of the synthesized pyridazinones were elucidated on the basis of their spectral analysis (IR, 1H-NMR, ...
متن کاملGreen Synthesis and Antihypertensive Activity of Some Mannich Bases of 1, 4 Dihydropyridine Compounds
Some new Mannich Bases of 1, 4 Dihydropyridine derivatives were synthesised by reaction of 1, 4 Dihydropyridine derivatives formaldehyde (HCHO) & secondary amines (e.g. morpholine, 1-methyl piperazine) in 1:1 ratio under acidic condition in presence of trace HCl. The compounds synthesised were identified by UV, 1H NMR, and FT-IR spectroscopic techniques. All compounds studied in this work were ...
متن کاملsynthesis and antihypertensive activity of novel 4-[1-(4-x-benzyl)-5-imidazolyl] dihydropyridines in rat
a series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-x -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (x=h, f) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (doca)-induced hypertension in rats. amlodipine was used as the standard dihydropyridine. all compounds tested showed lower antihypertensive activity than that of amlodipi...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1983
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.31.3186